McLEAN Kelley C, James Andra H
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont Larner College of Medicine, Burlington, Vermont.
Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, North Carolina.
Clin Obstet Gynecol. 2018 Jun;61(2):206-218. doi: 10.1097/GRF.0000000000000354.
Venous thromboembolism is a leading cause of maternal death. Because of the low absolute frequency of events, however, outcome-based clinical data are limited. Consequently, clinicians must additionally rely both on published guidelines and on extrapolation of data from studies focused on nonpregnant individuals. The diagnosis and treatment of deep vein thrombosis, pulmonary embolism, and cerebral vein and dural sinus thrombosis are complicated by pregnancy, and often require modifications to standard diagnostic and treatment algorithms outside of pregnancy. Treatment of VTE in pregnant women is in particular need of future research.
静脉血栓栓塞是孕产妇死亡的主要原因。然而，由于此类事件的绝对发生率较低，基于结果的临床数据有限。因此，临床医生还必须依赖已发表的指南以及来自针对非孕妇个体的研究数据推断。妊娠会使深静脉血栓形成、肺栓塞以及脑静脉和硬脑膜窦血栓形成的诊断和治疗变得复杂，通常需要对非妊娠状态下的标准诊断和治疗算法进行调整。孕妇静脉血栓栓塞症的治疗尤其需要未来的研究。
