RTI-Health Solutions, 200 Park Offices Drive, Research Triangle Park, NC, 27709, USA.
University of North Carolina at Chapel Hill Department of Health Policy and Management, Chapel Hill, NC, USA.
Support Care Cancer. 2018 Aug;26(8):2663-2673. doi: 10.1007/s00520-018-4110-8. Epub 2018 Feb 22.
The primary objective of this study was to evaluate the relationship between exercise and sleep disturbance in a sample of individuals diagnosed with stage I, II, and III colorectal cancer (CRC) as patients transitioned off first-line treatment. We also sought to identify heterogeneity in the relationship between sleep disturbance and exercise.
Data were obtained from the MY-Health study, a community-based observational study of adults diagnosed with cancer. Patient-Reported Outcomes Measurement Information System® (PROMIS) measures (e.g., PROMIS Sleep) were administered, and participants self-reported demographics, comorbidities, cancer treatment, and exercise. Regression mixture and multiple regression models were used to evaluate the relationship between sleep disturbance and exercise cross-sectionally at an average of 10 months after diagnosis, and the change in sleep disturbance over a 7-month period, from approximately 10 to 17 months post-diagnosis.
Patients whose exercise was categorized as likely at or above American College of Sports Medicine's guidelines did not report statistically better sleep quality compared to patients who were classified as not active. However, retirement (B = - 2.4), anxiety (B = 0.21), and fatigue (B = 0.24) had statistically significant relationships with sleep disturbance (p < 0.05). Increase in exercise was not significantly associated with a decrease in sleep disturbance. No statistical heterogeneity was revealed in the relationship between sleep and exercise.
Further prospective research using an objective measure of exercise is warranted to confirm or refute the nature of the relationship between exercise and sleep disturbance in individuals diagnosed with CRC transitioning off first-line treatment.
本研究的主要目的是评估在接受一线治疗的个体中，患有 I 期、II 期和 III 期结直肠癌 (CRC) 的个体过渡到一线治疗时，运动与睡眠障碍之间的关系。我们还试图确定睡眠障碍与运动之间的关系的异质性。
数据来自基于社区的 MY-Health 研究，该研究针对的是被诊断患有癌症的成年人。患者报告的结局测量信息系统 (PROMIS) 测量（例如，PROMIS 睡眠）被管理，参与者自我报告人口统计学数据、合并症、癌症治疗和运动。回归混合物和多元回归模型用于评估诊断后平均 10 个月时睡眠障碍与运动之间的横断面关系，以及从大约 10 到 17 个月诊断后睡眠障碍的变化。
将运动分类为符合或高于美国运动医学学院指南的患者与被归类为不活跃的患者相比，睡眠质量没有统计学上的改善。然而，退休（B = -2.4）、焦虑（B = 0.21）和疲劳（B = 0.24）与睡眠障碍有统计学显著关系（p < 0.05）。运动的增加与睡眠障碍的减少没有显著相关性。睡眠和运动之间的关系没有显示出统计学上的异质性。
需要进一步使用客观的运动测量方法进行前瞻性研究，以证实或反驳在接受一线治疗的 CRC 个体过渡到一线治疗时运动与睡眠障碍之间关系的性质。
