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Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality and morbidity. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.