Duman'yan E S, Skopets A A, Malyshev Y R, Porhanov V A
Anesteziol Reanimatol. 2016 Jul;61(4):308-310.
Guidelines recommend that duration of antibiotic prophylaxis in cardiac surgery should be no more than 48 h, but at the same time it has been suggested that a 24h or even a single dose may be sufficient.
To define whether 24-hour antibiotic prophylaxis on the incidence of infectious complications in cardiac surgery compared to the 72-hour period. Materials andmethods. All 125 patients were operatedfrom 01.01.2014 till 01.10.2014. All preoperative, intra and postoperative data were analyzed. Group 1 (n = 56) - these patients were administered cefazolinfor 24 h antibiotic prophylaxis (3 g/day); group 2 (n = 69) -patients with cefazolin for 72 h antibiotic prophylaxis (1 g every 8 h). Pre and intraoperative characteristics were the same in both groups.
Duration of stay in intensive care unit (ICU), postoperative hospitalization, sternomediastinitis frequency were also similar in both groups. The frequency of nosocomial pneumonia and rate ofprescription of antibiotics after antibiotic prophylaxis was significantly higher in group 1.
24-hour antibiotic prophylaxis does not increase the frequency of the surgical field's infection, but the frequency of postoperative pneumonia and change of antibiotic prophylaxis on antibiotic therapy was higher in group 1.
指南建议心脏手术中抗生素预防的持续时间不应超过48小时，但同时也有人提出24小时甚至单次剂量可能就足够了。
确定与72小时相比，24小时抗生素预防对心脏手术感染并发症发生率的影响。材料与方法。所有125例患者于2014年1月1日至2014年10月1日接受手术。分析所有术前、术中和术后数据。第1组（n = 56）——这些患者接受头孢唑林24小时抗生素预防（3克/天）；第2组（n = 69）——患者接受头孢唑林72小时抗生素预防（每8小时1克）。两组的术前和术中特征相同。
两组在重症监护病房（ICU）的住院时间、术后住院时间、胸骨纵隔炎发生率也相似。第1组医院获得性肺炎的发生率和抗生素预防后抗生素处方率显著更高。
24小时抗生素预防不会增加手术部位感染的发生率，但第1组术后肺炎的发生率和抗生素预防后抗生素治疗的改变更高。
