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[如何在治疗方案中最佳地使用现有药物?]

[How to Optimally Use Currently Available Drugs in a Therapeutic Algorithm?].

作者信息

Kim You Sun

机构信息

Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

出版信息

Korean J Gastroenterol. 2018 Feb 25;71(2):74-80. doi: 10.4166/kjg.2018.71.2.74.

Abstract

Recently, the incidence and prevalence of inflammatory bowel disease (IBD) have been increasing in worldwide, especially in Asian area. IBD is a chronic and progressive disease eventually causing bowel damage. The advance in the treatment of IBD over the past several decades has been achieved with the development of biologics. Furthermore, goals for management of IBD have been evolving from symptom-based management to mucosal healing, which can reduce the surgery rate and hospitalization. To treat the patients with IBD properly, identification of risk factors of patients should be preceded. In addition, the knowledge of several drugs, which are available in current situation is essential. In this review, optimal therapeutic approach with drugs including 5-aminosalicylate, steroid, immunomodulators and anti-TNF antagonists is discussed.

摘要

近年来,炎症性肠病(IBD)在全球范围内的发病率和患病率一直在上升,尤其是在亚洲地区。IBD是一种慢性进行性疾病,最终会导致肠道损伤。在过去几十年中,随着生物制剂的发展,IBD的治疗取得了进展。此外,IBD的管理目标已从基于症状的管理转变为黏膜愈合,这可以降低手术率和住院率。为了正确治疗IBD患者,应先识别患者的风险因素。此外,了解当前可用的几种药物的知识至关重要。在这篇综述中,讨论了包括5-氨基水杨酸、类固醇、免疫调节剂和抗TNF拮抗剂在内的药物的最佳治疗方法。

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