Dimitrov Evgeni, Enchev Emil, Halacheva Krasimira, Minkov Georgi, Yovtchev Yovcho
1 Department of Surgical Diseases, University Hospital "Prof. Dr. Stoyan Kirkovich" , Stara Zagora, Bulgaria.
2 Faculty of Medicine, Department of Immunology, Trakia University , Stara Zagora, Bulgaria.
Acta Microbiol Immunol Hung. 2018 Aug 1;65(3):245-254. doi: 10.1556/030.65.2018.011. Epub 2018 Feb 23.
Complicated intra-abdominal infections (cIaIs) respresent a serious cause of morbidity and mortality. Early diagnosis and well-timed treatment can improve patients' outcome, whereas the delay in management often result in rapid progression to circulatory collapse, multiple organ failure, and death. Neutrophil CD64 antigen expression has been studied for several years as infectious and sepsis biomarker and has several characteristics that make it good for clinical employment. It has been suggested to be predictive of positive bacterial cultures and a useful test for management of sepsis and other significant bacterial infections. Our review concluded that the neutrophil CD64 expression could be a promising and meaningful biomarker in patients with cIaIs. It shows good potential for evaluating the severity of the disease and could give information about the outcome. However, more large studies should be performed before using it in clinical practice.
复杂性腹腔内感染（cIAIs）是发病和死亡的严重原因。早期诊断和及时治疗可改善患者预后，而治疗延迟往往导致迅速进展为循环衰竭、多器官功能衰竭和死亡。中性粒细胞CD64抗原表达作为感染和脓毒症生物标志物已研究多年，具有一些有利于临床应用的特征。它被认为可预测细菌培养阳性，是脓毒症和其他严重细菌感染管理的有用检测方法。我们的综述得出结论，中性粒细胞CD64表达可能是cIAIs患者中有前景且有意义的生物标志物。它在评估疾病严重程度方面显示出良好潜力，并可提供有关预后的信息。然而，在临床实践中使用它之前，应进行更多大型研究。
