Chen Xiaolin, O'Halloran John, Jansen Marcel A K
a School of Biological, Earth and Environmental Sciences, University College Cork , Cork , Ireland.
b Environmental Research Institute, University College Cork , Cork , Ireland.
Environ Technol. 2019 Jul;40(18):2446-2454. doi: 10.1080/09593330.2018.1445299. Epub 2018 Mar 2.
Because of their applications in large numbers of products, Zinc Oxide nanoparticles (nano-ZnO) will inevitably enter into the environment. Nano-ZnO released into the environment will be present in a complex matrix which can cause various chemical and physical transformations and modulate the biological reactivity of these particles. Due to their rapid growth and small size, is recommended by OECD for toxicological testing. Here, we tested how nano-ZnO reactivity is modulated by the suite of macro- and micronutrients that are present in growth media. Specifically, we measured Reactive Oxygen Species (ROS) formation by nano-ZnO, and subsequent toxicity. The data show how orthophosphate can modulate both ROS formation, and toxicity. This has ramifications for phytotoxicity testing, which is commonly performed under controlled conditions and on media containing orthophosphate.
由于大量产品中都有应用，氧化锌纳米颗粒（纳米氧化锌）将不可避免地进入环境。释放到环境中的纳米氧化锌会存在于复杂的基质中，这可能导致各种化学和物理转化，并调节这些颗粒的生物反应性。由于其快速生长和小尺寸，经合组织建议对其进行毒理学测试。在此，我们测试了生长培养基中存在的大量和微量营养素如何调节纳米氧化锌的反应性。具体而言，我们测量了纳米氧化锌产生的活性氧（ROS）以及随后的毒性。数据显示了正磷酸盐如何调节ROS的形成和毒性。这对植物毒性测试有影响，植物毒性测试通常在受控条件下并在含有正磷酸盐的培养基上进行。
