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Increased receptor activity-modifying protein 1 in the nervous system is sufficient to protect against autonomic dysregulation and hypertension.神经系统中受体活性修饰蛋白 1 的增加足以防止自主神经失调和高血压。
J Cereb Blood Flow Metab. 2019 Apr;39(4):690-703. doi: 10.1177/0271678X17751352. Epub 2018 Jan 3.
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A Controlled Trial of Erenumab for Episodic Migraine.依瑞奈玛单抗治疗发作性偏头痛的对照试验。
N Engl J Med. 2017 Nov 30;377(22):2123-2132. doi: 10.1056/NEJMoa1705848.
3
Fremanezumab for the Preventive Treatment of Chronic Migraine.氟雷马尼布用于慢性偏头痛的预防性治疗。
N Engl J Med. 2017 Nov 30;377(22):2113-2122. doi: 10.1056/NEJMoa1709038.
4
Blocking CGRP in migraine patients - a review of pros and cons.阻断偏头痛患者的降钙素基因相关肽——利弊综述
J Headache Pain. 2017 Sep 25;18(1):96. doi: 10.1186/s10194-017-0807-1.
5
Migraine, Neurogenic Inflammation, Drug Development - Pharmacochemical Aspects.偏头痛、神经源性炎症与药物研发——药物化学方面
Curr Med Chem. 2017;24(33):3649-3665. doi: 10.2174/0929867324666170712163437.
6
The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine.三叉血管通路：降钙素基因相关肽及其受体在偏头痛中的作用。
Headache. 2017 May;57 Suppl 2:47-55. doi: 10.1111/head.13081.
7
Pathophysiology of Migraine: A Disorder of Sensory Processing.偏头痛的病理生理学：一种感觉处理障碍
Physiol Rev. 2017 Apr;97(2):553-622. doi: 10.1152/physrev.00034.2015.
8
Wiping Out CGRP: Potential Cardiovascular Risks.消除 CGRP：潜在的心血管风险。
Trends Pharmacol Sci. 2016 Sep;37(9):779-788. doi: 10.1016/j.tips.2016.06.002. Epub 2016 Jun 21.
9
CGRP as a neuropeptide in migraine: lessons from mice.降钙素基因相关肽作为偏头痛中的一种神经肽：来自小鼠的经验教训。
Br J Clin Pharmacol. 2015 Sep;80(3):403-14. doi: 10.1111/bcp.12686. Epub 2015 Jul 14.
10
Migraine pathophysiology: lessons from mouse models and human genetics.偏头痛发病机制：来自小鼠模型和人类遗传学的启示。
Lancet Neurol. 2015 Jan;14(1):65-80. doi: 10.1016/S1474-4422(14)70220-0.

降钙素基因相关肽（受体）抗体：偏头痛治疗的新途径。

Calcitonin gene-related peptide (receptor) antibodies: an exciting avenue for migraine treatment.

机构信息

Department of Internal Medicine, Division of Vascular Medicine and Pharmacology, Erasmus MC, Rotterdam, The Netherlands.

Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.

出版信息

Genome Med. 2018 Feb 22;10(1):10. doi: 10.1186/s13073-018-0524-7.

DOI:10.1186/s13073-018-0524-7
PMID:29471874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5824555/
Abstract

Specific prophylactic migraine treatments are urgently needed because of the unmet needs of many migraine patients. Antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor have recently shown efficacy in episodic and chronic migraine and will be available soon.

摘要

由于许多偏头痛患者的需求未得到满足，因此迫切需要特定的预防性偏头痛治疗方法。针对降钙素基因相关肽 (CGRP) 或其受体的抗体最近已显示出在发作性和慢性偏头痛中的疗效，并且很快将上市。