Uganda-Case Western Reserve University Research Collaboration, Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio, Division of Infectious Diseases, MetroHealth Medical Center, Cleveland, Ohio, USA.
Uganda-Case Western Reserve University Research Collaboration, Tuberculosis Research Unit, Case Western Reserve University and University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Int J Tuberc Lung Dis. 2018 Mar 1;22(3):306-308. doi: 10.5588/ijtld.17.0655.
The sputum smear-positive, culture-negative state poses a challenge for clinicians. Previous studies have shown that most samples with positive smears during the later stages of treatment are culture-negative. Earlier studies generally used solid culture media, which tend to be less sensitive than current liquid culture systems. We examined the smear-positive, culture-negative state in the era of MGIT™ 960™ liquid cultures. We found that the smear-positive, culture-negative state occurred less frequently with MGIT culture, and that the majority of the samples with late positive smears were culture-negative, regardless of media type.
涂阳培阴状态给临床医生带来了挑战。既往研究显示，治疗后期阳性涂片的大多数样本培养结果为阴性。既往研究通常使用固体培养基，其敏感性一般低于目前的液体培养系统。我们检测了 MGIT™ 960™液体培养时代的涂阳培阴状态。我们发现，MGIT 培养时涂阳培阴状态的发生率较低，且无论培养基类型如何，大多数晚期阳性涂片的样本培养结果为阴性。
