与多发性硬化症患者的特立氟胺相关的严重高甘油三酯血症：一例报告。
Severe hypertriglyceridemia associated with teriflunomide in a patient with multiple sclerosis: A case report.
机构信息
Department of Clinical Neurosciences and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada/Servicio de Neurología, Hospital Universitario "Dr. José E. González," Universidad Autónoma de Nuevo León, Monterrey, México.
Servei de Neurología-Neuroimmunologia, Centre d'Esclerosi Múltiple de Catalunya (Cemcat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
出版信息
Mult Scler. 2018 Sep;24(10):1383-1385. doi: 10.1177/1352458518761185. Epub 2018 Feb 23.
OBJECTIVE
To describe a case of severe hypertriglyceridemia in a patient receiving teriflunomide.
METHODS
This is a case study.
RESULTS
Our patient developed severe hypertriglyceridemia (>5000 mg/dL) while on teriflunomide. The drug was withdrawn. Resolution began over 3 weeks later.
CONCLUSION
We describe the first probable case of teriflunomide-associated severe hypertriglyceridemia in a patient with multiple sclerosis, an adverse event previously associated with leflunomide in patients with rheumatologic diseases. Clinicians should be aware of this rare but potentially dangerous adverse event.
目的
描述一例接受特立氟胺治疗的患者出现严重高甘油三酯血症。
方法
这是一个病例研究。
结果
我们的患者在接受特立氟胺治疗期间出现严重高甘油三酯血症（>5000mg/dL）。停用该药物。3 周后开始缓解。
结论
我们描述了首例多发性硬化症患者使用特立氟胺相关的严重高甘油三酯血症的可能病例，这是一种先前与风湿性疾病患者使用来氟米特相关的不良事件。临床医生应意识到这种罕见但潜在危险的不良事件。
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