Usonis V, Kühnl P, Brede H D, Doerr H W
Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Sep;262(3):377-84. doi: 10.1016/s0176-6724(86)80011-6.
Three injections monthly of 50 micrograms/ml hepatitis-B-vaccine (Hevac-B-Pasteur) and one booster injection after 12 months from the beginning of vaccination were given to 676 adult recipients. Anti-HBs was detected in 45.9 percent of persons one month after the first dose of vaccine, in 79.3 percent after the third dose and in 98.4 percent after the booster injection. A follow-up of 142 persons 3 years after the first dose of vaccine indicated that protective levels of anti-HBs were maintained in 95.1 per cent of all participants. HLA antigens were typed in 13 vaccine recipients with low anti-HBs titers (less than or equal to 10 ImU/ml) and in 26 recipients with high anti-HBs titers (greater than or equal to 20,000 ImU/ml). Significant differences of antigen frequency (p less than 0.05) were found for HLA A3 (decrease in high responders), and HLA DR7 (increase of in low, decrease in high responders). The results indicate genetic differences between high and low responding recipients of HBV vaccine.
对676名成年接种者每月注射3次50微克/毫升的乙肝疫苗（Hevac - B - 巴斯德），并在开始接种疫苗12个月后进行1次加强注射。在接种第一剂疫苗1个月后，45.9%的人检测到抗 - HBs；在接种第三剂后，79.3%的人检测到抗 - HBs；在加强注射后，98.4%的人检测到抗 - HBs。对142名接种者在接种第一剂疫苗3年后进行随访，结果显示95.1%的参与者抗 - HBs水平维持在保护水平。对13名抗 - HBs滴度低（小于或等于10国际单位/毫升）的疫苗接种者和26名抗 - HBs滴度高（大于或等于20,000国际单位/毫升）的接种者进行了HLA抗原分型。发现HLA A3（高反应者中减少）和HLA DR7（低反应者中增加，高反应者中减少）的抗原频率存在显著差异（p小于0.05）。结果表明乙肝疫苗高反应者和低反应者之间存在遗传差异。
