Alzuhairi Karam Sadoon, Søgaard Peter, Ravkilde Jan, Gislason Gunnar, Køber Lars, Torp-Pedersen Christian
Department of Cardiology, Aalborg University Hospital, Hobrovej 18, Aalborg DK-9000, Denmark.
Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Eur Heart J Qual Care Clin Outcomes. 2015 Nov 1;1(2):72-78. doi: 10.1093/ehjqcco/qcv016.
To examine temporal changes in incidence and 1-year mortality of first myocardial infarction (MI) in different age groups for both genders in Denmark over a 35-year period (1978-2012).
Patients aged 30 years or older admitted with first MI in Denmark from 1978 to 2012 were included (n = 316 790). Overall, first MI incidence per 100 000 person-years (/105 p.y.) decreased significantly from 500 to 297/105 p.y. for males and from 229 to 156/105 p.y. for females. The decline was greatest among men aged 70-79 from 1460 to 643/105 p.y. (-56%). The majority of age groups also experienced declining incidence. However, men aged 30-39 and ≥90 years as well as females aged 30-49 and ≥90 years had increasing incidence during the study period. Moreover, the incidence decreased from 1978 to 1996 among males aged 40-49 and females aged 50-59 years, but increased in the remainder of the study period. One-year case-fatality declined significantly from 50 to 9% of MI male patients, and from 53 to 15% of MI female patients when comparing 1978 to 2012. Statistical analysis with Poisson models demonstrated that the mortality rate increased with age and decreased with time and indicated no significant difference between genders.
During the period from 1978 to 2012, there was a significant decline in MI incidence among most age groups for both genders; however, an incidence increase was observed in men under 50 and women under 60 years, and ≥90 years for both genders. One-year case-fatality decreased constantly during the study period.
研究丹麦35年间（1978 - 2012年）不同年龄组男女首次心肌梗死（MI）发病率及1年死亡率的时间变化。
纳入1978年至2012年在丹麦因首次心肌梗死入院的30岁及以上患者（n = 316790）。总体而言，男性每10万人年首次心肌梗死发病率（/10⁵人年）从500显著降至297/10⁵人年，女性从229降至156/10⁵人年。70 - 79岁男性发病率下降幅度最大，从1460降至643/10⁵人年（-56%）。大多数年龄组发病率也呈下降趋势。然而，研究期间30 - 39岁男性、90岁及以上男性以及30 - 49岁女性、90岁及以上女性发病率呈上升趋势。此外，40 - 49岁男性和50 - 59岁女性的发病率在1978年至1996年下降，但在研究期其余时间上升。比较1978年至2012年，男性心肌梗死患者1年病死率从50%显著降至9%，女性从53%降至15%。泊松模型统计分析表明，死亡率随年龄增加而上升，随时间下降，且两性之间无显著差异。
1978年至2012年期间，大多数年龄组男女的心肌梗死发病率显著下降；然而，50岁以下男性、60岁以下女性以及90岁及以上男女发病率呈上升趋势。研究期间1年病死率持续下降。
