University of California, San Diego, San Diego, California, USA.
The Center for Clinical Research, LLC, Winston Salem, North Carolina.
Pain Med. 2018 Jul 1;19(7):1425-1435. doi: 10.1093/pm/pnx325.
Despite the high prevalence of chronic multisite pain, there is little consensus on methods to characterize it. Commonly used assessments report only one dimension of pain, that is, intensity, thus ignoring the spatial aspect of pain. We developed a novel pain quantification index, the Integrated Pain Quantification Index (IPQI), on a scale of 0 to 1 that integrates multiple distinct pain measures into a single value, thus representing multidimensional pain information with a single value.
Single-visit, noninterventional, epidemiological study.
Fourteen outpatient multidisciplinary pain management programs.
Patients with chronic pain of the trunk and/or limbs for at least six months with average overall pain intensity of at least 5 on the numeric rating scale.
Development of IPQI was performed in a large population (N = 810) of chronic pain patients from the Multiple Areas of Pain (MAP) study.
Prevalence of two or more noncontiguous painful areas was at 88.3% (95% confidence interval [CI] = 0.86-0.90), with a mean of 6.3 areas (SD = 5.57 areas). Prevalence of more than 10% body area in pain was at 52.8% (95% CI = 0.49-0.56), with a mean at 16.1% (17.16%). On average, IPQI values were near the middle of the scale, with mean and median IPQI at 0.52 (SD = 0.13) and 0.55, respectively. The IPQI was generalizable and clinically relevant across all domains recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials.
IPQI provided a single pain score for representing complex, multidimensional pain information on one scale and has implications for comparing pain populations across longitudinal clinical trials.
尽管慢性多部位疼痛的患病率很高，但对于如何描述这种疼痛，目前还没有达成共识。常用的评估方法仅报告疼痛的一个维度，即强度，从而忽略了疼痛的空间方面。我们开发了一种新的疼痛量化指数，即综合疼痛量化指数（IPQI），其范围为 0 到 1，将多个不同的疼痛测量值整合为一个单一的值，从而用一个单一的值来表示多维疼痛信息。
单次就诊、非干预性、流行病学研究。
14 个门诊多学科疼痛管理计划。
慢性躯干和/或四肢疼痛至少 6 个月，平均总体疼痛强度至少为数字评分量表的 5 分。
在来自多部位疼痛（MAP）研究的大量慢性疼痛患者（N=810）中进行了 IPQI 的开发。
两个或更多非连续疼痛部位的患病率为 88.3%（95%置信区间[CI] = 0.86-0.90），平均为 6.3 个部位（SD=5.57 个部位）。疼痛涉及 10%以上身体区域的患病率为 52.8%（95%CI=0.49-0.56），平均为 16.1%（17.16%）。平均而言，IPQI 值接近量表的中间位置，平均和中位数 IPQI 分别为 0.52（SD=0.13）和 0.55。IPQI 具有普遍性，并且在临床试验中方法、测量和疼痛评估倡议推荐的所有领域都具有临床相关性。
IPQI 提供了一个单一的疼痛评分，用于在一个量表上表示复杂的多维疼痛信息，并且对比较纵向临床试验中的疼痛人群具有重要意义。
