自然杀伤细胞肠病：10 年惰性临床行为的病例报告。
NK cell enteropathy: a case report with 10 years of indolent clinical behaviour.
机构信息
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.
Department of Medicine, Division of Gastroenterology University of Florida College of Medicine, Gainesville, FL, USA.
出版信息
Histopathology. 2018 Aug;73(2):345-350. doi: 10.1111/his.13502. Epub 2018 May 21.
AIMS
Natural killer (NK) cell enteropathy is a recently described clinically indolent condition characterised by atypical NK cell infiltrates in the gastrointestinal mucosa that mimics malignant lymphoma. We report a case that highlights the indolent clinical behaviour by documenting absence of clinical progression over 10 years.
METHODS AND RESULTS
We report the case of a 69-year old female who had clinically long-standing abdominal pain and recurrent mucosal ulcerations associated with atypical NK cell infiltrates. The clinical, morphologic and immunophenotypical findings in this case were diagnostic of NK cell enteropathy. Review of the patient's prior biopsies demonstrated that this persisted without clinical progression for 10 years, confirming the clinical indolent course.
CONCLUSION
Recognition of NK cell enteropathy is important to avoid over-diagnosing this benign condition as an aggressive lymphoma.
目的
自然杀伤 (NK) 细胞肠病是一种新近描述的临床惰性疾病，其特征为胃肠道黏膜存在非典型 NK 细胞浸润，类似于恶性淋巴瘤。我们报告了一例病例，该病例 10 年来无临床进展，提示其具有惰性的临床行为。
方法和结果
我们报告了一例 69 岁女性患者的病例，其具有长期临床腹痛和复发性黏膜溃疡，伴有非典型 NK 细胞浸润。该病例的临床、形态学和免疫表型发现诊断为 NK 细胞肠病。对患者先前活检的回顾表明，该疾病持续存在，无临床进展达 10 年，证实了其临床惰性病程。
结论
认识到 NK 细胞肠病很重要，可避免将这种良性疾病误诊为侵袭性淋巴瘤。
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