Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kidney Int. 2018 Mar;93(3):538-540. doi: 10.1016/j.kint.2017.09.025.
Mesoamerican nephropathy is a progressive, often fatal form of tubulointerstitial nephritis affecting young agricultural laborers in Central America. Initially described as a chronic disease, a study by Fischer and coworkers in this issue of Kidney International suggests that Mesoamerican nephropathy goes through an active, inflammatory phase. Although the pathologic findings are nonspecific and the etiology of Mesoamerican nephropathy remains unclear, inflammatory infiltrates in areas of evolving and established interstitial fibrosis appear to cause progressive kidney injury.
中美洲肾病是一种进行性、常致命的肾小管间质性肾炎，影响中美洲的年轻农业劳动者。最初被描述为一种慢性疾病，Fischer 及其同事在本期《肾脏国际》中的研究表明，中美洲肾病经历一个活跃的炎症阶段。尽管病理发现是非特异性的，中美洲肾病的病因仍不清楚，但在进行性和已确立的间质纤维化区域的炎症浸润似乎导致进行性肾损伤。
