From the Department of Medical Physiology, Texas A&M College of Medicine, College Station.
Circ Res. 2018 Apr 13;122(8):1094-1101. doi: 10.1161/CIRCRESAHA.118.312765. Epub 2018 Feb 23.
Hypertension is associated with renal infiltration of activated immune cells; however, the role of renal lymphatics and immune cell exfiltration is unknown.
We tested the hypotheses that increased renal lymphatic density is associated with 2 different forms of hypertension in mice and that further augmenting renal lymphatic vessel expansion prevents hypertension by reducing renal immune cell accumulation.
Mice with salt-sensitive hypertension or nitric oxide synthase inhibition-induced hypertension exhibited significant increases in renal lymphatic vessel density and immune cell infiltration associated with inflammation. Genetic induction of enhanced lymphangiogenesis only in the kidney, however, reduced renal immune cell accumulation and prevented hypertension.
These data demonstrate that renal lymphatics play a key role in immune cell trafficking in the kidney and blood pressure regulation in hypertension.
高血压与肾脏中活化免疫细胞的浸润有关；然而，肾脏淋巴管和免疫细胞外渗的作用尚不清楚。
我们检验了以下假说，即在小鼠中，增加肾脏淋巴管密度与 2 种不同形式的高血压相关，并且进一步增加肾脏淋巴管扩张可通过减少肾脏免疫细胞积聚来预防高血压。
盐敏感性高血压或一氧化氮合酶抑制诱导的高血压小鼠的肾脏淋巴管密度和与炎症相关的免疫细胞浸润显著增加。然而，仅在肾脏中诱导增强的淋巴管生成的基因，可减少肾脏免疫细胞积聚并预防高血压。
这些数据表明，肾脏淋巴管在肾脏中免疫细胞的迁移和高血压的血压调节中起关键作用。
