Preece P E, Zippel H H
Acta Cytol. 1979 Mar-Apr;23(2):163-8.
Literature relating X-chromatin with the histologic grade in carcinoma of the breast is briefly reviewed. X-chromatin incidence has been determined in 14 cases of lobular neoplasia and 5 invasive lobular carcinomas of the breast and has been correlated with the DNA content in these sections examined by Feulgen microspectrophotometry. In 11 of the cases of lobular neoplasia, the DNA values fell within the diploid range and in the 3 remaining cases within the diploid to tetraploid range, while the 5 invasive lobular carconomas showed a DNA distribution between the diploid and tetraploid ranges. The X-chromatin counts of these cases were variable but did not correlate with the cytophotometrically observed degree of malignancy in lobular neoplasia. No statistically significant differences in X-chromatin count of lobular neoplasia and invasive lobular carcinoma could be seen.
简要回顾了关于X染色质与乳腺癌组织学分级的相关文献。已测定了14例乳腺小叶瘤和5例浸润性小叶癌的X染色质发生率，并将其与通过福尔根显微分光光度法检测的这些切片中的DNA含量相关联。在11例小叶瘤病例中，DNA值落在二倍体范围内，其余3例在二倍体至四倍体范围内，而5例浸润性小叶癌的DNA分布在二倍体和四倍体范围内。这些病例的X染色质计数各不相同，但与小叶瘤中细胞光度法观察到的恶性程度无关。小叶瘤和浸润性小叶癌的X染色质计数未见统计学上的显著差异。
