Department of Radiology, University of Yamanashi, Yamanshi, Japan.
GE Healthcare Japan, Tokyo, Japan.
Magn Reson Med. 2018 Oct;80(4):1546-1555. doi: 10.1002/mrm.27151. Epub 2018 Feb 24.
To develop multiparameter mapping including T , R2*, and proton density fat fraction with a single breath-hold to evaluate liver disease and liver function.
A 6-echo spoiled gradient-echo sequence with dual flip angles was used to acquire a 12-set MRI volume data set. To shorten the scan time, undersampling and multicontrast compressed-sensing reconstruction were used. The scan time was 18 seconds. R2* and proton density fat fraction mapping were achieved by using the iterative least-squares method. T mapping was estimated using driven equilibrium single-pulse observation of T . Quantitative values were validated by performing phantom and volunteer studies.
Statistical analysis showed that the quantitative values measured using the proposed methods agreed with those measured using conventional methods. T values of water proton measured by the proposed method in phantom and volunteer studies were in good agreement with those by MRS.
The results showed that accurate quantitative mapping of T , R2*, and proton density fat fraction with a single breath-hold was achieved using our approach.
开发一种单屏气控制多参数图，包括 T 1 、 R2* 和质子密度脂肪分数，以评估肝脏疾病和肝功能。
使用双翻转角的 6 回波扰相梯度回波序列采集 12 组 MRI 体数据集。为了缩短扫描时间，使用欠采样和多对比压缩感知重建。扫描时间为 18 秒。通过迭代最小二乘法实现 R2*和质子密度脂肪分数图。通过驱动平衡单脉冲 T1 观察法估计 T1 图。通过进行体模和志愿者研究来验证定量值。
统计分析表明，所提出的方法测量的定量值与传统方法测量的定量值一致。体模和志愿者研究中，所提出的方法测量的水质子 T1 值与 MRS 测量的 T1 值吻合良好。
结果表明，该方法可实现单次屏气下 T1 、 R2* 和质子密度脂肪分数的准确定量图。
