疼痛的潜意识（潜在）加工及其向意识的演变。
Subliminal (latent) processing of pain and its evolution to conscious awareness.
机构信息
Center for Pain and the Brain, 9 Hope Avenue, Mailbox 26, Waltham, MA, 06524-9936, United States.
Center for Pain and the Brain, 9 Hope Avenue, Mailbox 26, Waltham, MA, 06524-9936, United States.
出版信息
Neurosci Biobehav Rev. 2018 May;88:1-15. doi: 10.1016/j.neubiorev.2018.02.015. Epub 2018 Feb 21.
Abstract
By unconscious or covert processing of pain we refer to nascent interactions that affect the eventual deliverance of pain awareness. Thus, internal processes (viz., repeated nociceptive events, inflammatory kindling, reorganization of brain networks, genetic) or external processes (viz., environment, socioeconomic levels, modulation of epigenetic status) contribute to enhancing or inhibiting the presentation of pain awareness. Here we put forward the notion that for many patients, ongoing sub-conscious changes in brain function are significant players in the eventual manifestation of chronic pain. In this review, we provide clinical examples of nascent or what we term pre-pain processes and the neurobiological mechanisms of how these changes may contribute to pain, but also potential opportunities to define the process for early therapeutic interventions.
摘要
我们所说的无意识或隐性疼痛处理是指那些影响最终疼痛感知的初生相互作用。因此，内部过程（即，反复的伤害性事件、炎症性点燃、大脑网络的重组、遗传）或外部过程（即，环境、社会经济水平、表观遗传状态的调节）有助于增强或抑制疼痛感知的呈现。在这里，我们提出这样一种观点，即对于许多患者来说，大脑功能的持续无意识变化是慢性疼痛最终表现的重要因素。在这篇综述中，我们提供了初生或我们称之为预疼痛过程的临床实例，以及这些变化如何有助于疼痛的神经生物学机制，但也为早期治疗干预定义这一过程提供了潜在的机会。
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