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慢张力禽类肌肉背阔皮肌移植物中纤维类型的发育

The development of fibre types in grafts of a slow tonic avian muscle, the dorsocutaneous latissimus dorsi.

作者信息

Grounds M D

出版信息

Cell Differ. 1986 Oct;19(3):207-24. doi: 10.1016/0045-6039(86)90097-7.

DOI:10.1016/0045-6039(86)90097-7
PMID:2947696
Abstract

The dorsocutaneous (DLD) and anterior (ALD) latissimus dorsii are both homogeneous slow tonic muscles. Autografts of mature DLD were attached onto the ALD of chickens to study regeneration of slow tonic muscle fibres innervated exclusively by slow tonic nerves. Fifty-three grafts were examined from 3 to 231 days after implantation for myosin ATPase, and for heavy chains of fast myosin. New muscle fibres in grafts were initially type 1 (slow) or type 2 (fast twitch). Tonic type 3 fibres were slow to differentiate and were not seen within 59 days. From 105 days many fibres were type 3A and type 1 were no longer apparent. However, type 2 fibres persisted and appeared to be present instead of type 3B fibres even after 8 months.

摘要

背阔肌的背皮支(DLD)和前支(ALD)均为均质性慢张力肌。将成熟背阔肌背皮支的自体移植物附着于鸡的背阔肌前支上,以研究仅由慢张力神经支配的慢张力肌纤维的再生情况。在植入后3至231天,对53个移植物进行了肌球蛋白ATP酶和快肌球蛋白重链检测。移植物中的新肌纤维最初为1型(慢肌)或2型(快肌)。张力性3型纤维分化缓慢,在59天内未见。从105天起,许多纤维为3A型,1型纤维不再明显。然而,2型纤维持续存在,甚至在8个月后似乎取代了3B型纤维。

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