Lgr5 干细胞研究的最新进展。

Recent Advances in Lgr5 Stem Cell Research.

机构信息

A*STAR Institute of Medical Biology, 138648, Singapore; These authors contributed equally.

A*STAR Institute of Medical Biology, 138648, Singapore; Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan; Centre for Regenerative Medicine, The University of Edinburgh, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.

出版信息

Trends Cell Biol. 2018 May;28(5):380-391. doi: 10.1016/j.tcb.2018.01.010. Epub 2018 Feb 21.

DOI:10.1016/j.tcb.2018.01.010

PMID:29477614

Abstract

The discovery of leucine-rich repeat-containing G protein-coupled receptor 5 (Lgr5) as both a marker of adult stem cells and a critical modulator of their activity via its role as an effector of Wnt/R-spondin (Rspo) signaling has driven major advances in our understanding of stem cell biology during homeostasis, regeneration, and disease. Exciting new mouse and organoid culture models developed to study the endogenous behavior of Lgr5-expressing cells in health and disease settings have revealed the existence of facultative stem cell populations responsible for tissue regeneration, cancer stem cells (CSCs) driving metastasis in the gut, and Lgr5 niche cells in the lung. Here we review these recent advances and discuss their impact on efforts to harness the therapeutic potential of adult stem cells and their cancer counterparts in the clinic.

摘要

富含亮氨酸重复序列的 G 蛋白偶联受体 5（Lgr5）的发现，既是成体干细胞的标志物，也是其通过作为 Wnt/R-spondin（Rspo）信号的效应物来调节其活性的关键调节剂，这推动了我们对干细胞生物学在稳态、再生和疾病中的理解的重大进展。为了研究 Lgr5 表达细胞在健康和疾病环境中的内源性行为而开发的令人兴奋的新型小鼠和类器官培养模型，揭示了负责组织再生的多能干细胞群体、在肠道中驱动转移的癌症干细胞（CSC），以及肺部中的 Lgr5 生态位细胞的存在。在这里，我们回顾了这些最新进展，并讨论了它们对利用成年干细胞及其癌症对应物在临床上的治疗潜力的影响。