Santamaria J, Guillemi S, Osborne S, Coppin C, Dahlby R, Paré P D
Chest. 1987 Jan;91(1):86-90. doi: 10.1378/chest.91.1.86.
To assess the effectiveness and site of action of bronchodilatation with an inhaled anticholinergic bronchodilator, ipratropium bromide, and a beta adrenergic agonist, fenoterol, we measured the density dependence of maximal flow and the density dependence of pulmonary resistance using a digital computerized averaging circuit. Eight normal subjects were studied on two separate days, before and after the bronchodilators were administered in a double blind manner. Both drugs resulted in significant and equivalent bronchodilatation. However, there were no significant changes in the density dependence of maximal flow or pulmonary resistance with either agent. These results in normal subjects, therefore, do not support the hypothesis of a preferential site of action of inhaled anticholinergic agents and beta-adrenergic agents.
为了评估吸入性抗胆碱能支气管扩张剂异丙托溴铵和β肾上腺素能激动剂非诺特罗的支气管扩张效果及作用部位，我们使用数字计算机平均电路测量了最大流量的密度依赖性和肺阻力的密度依赖性。对8名正常受试者在两天内分别进行了研究，在双盲方式下给予支气管扩张剂之前和之后。两种药物均导致显著且等效的支气管扩张。然而，两种药物对最大流量或肺阻力的密度依赖性均无显著变化。因此，这些在正常受试者中的结果不支持吸入性抗胆碱能药物和β肾上腺素能药物存在优先作用部位的假设。
