YKL-40 在肿瘤生态位动态中的血管生成潜力。

Angiogenic potential of YKL-40 in the dynamics of tumor niche.

机构信息

Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.

Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

Biomed Pharmacother. 2018 Apr;100:478-485. doi: 10.1016/j.biopha.2018.02.050. Epub 2018 Feb 23.

DOI:10.1016/j.biopha.2018.02.050

PMID:29477911

Abstract

A multitude of clinical studies showed the elevation of YKL-40 in subjects with different kinds of tumors. It is predicted that an inherent correlation exists between survivals of cancer patients with total YKL-40 serum levels, making this factor as a potential novel biomarker. However, the crucial role of YKL-40 in the dynamics of cancers, especially angiogenesis, has not yet been completely addressed. In this review, we highlighted the various facets of YKL-40 and its importance in cancer biology as a bio-shuttle in gene therapy.

摘要

大量的临床研究表明，YKL-40 在不同类型的肿瘤患者中升高。有预测认为，癌症患者的总 YKL-40 血清水平与生存率之间存在内在相关性，这使得该因子成为一种有潜力的新型生物标志物。然而，YKL-40 在癌症动态，特别是血管生成中的关键作用尚未得到完全解决。在这篇综述中，我们强调了 YKL-40 的各个方面及其作为基因治疗中的生物穿梭在癌症生物学中的重要性。