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阻塞性睡眠呼吸暂停综合征对中枢听觉系统的影响。

The effect of obstructive sleep apnea syndrome on the central auditory system.

出版信息

Turk J Med Sci. 2018 Feb 23;48(1):5-9. doi: 10.3906/sag-1705-66.

Abstract

Background/aim: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by repeated hypoxia attacks during sleep. The effect of hypoxia on the central nervous system is a well-known entity. In this study we aimed to investigate the effect of OSAS on the central auditory system. Materials and methods: Twenty-one OSAS patients diagnosed by polysomnography (PSG) and 10 control subjects were included in the study. After a thorough otorhinolaryngology examination, all subjects underwent pure tone audiometry (250 to 8000 Hz frequency). The subjects with normal otoscopic examination and hearing threshold were included in the study. All participants underwent speech discrimination analyses and auditory time processing and sequencing tests, i.e. frequency pattern test (FPT) and duration pattern test (DPT). Results: Although hearing was normal in the OSAS patients, significant loss was observed in the speech discrimination rates compared to the control group (P < 0.05). Significant disruption was also detected in the FPT and SPT in the OSAS patients (P < 0.05). Conclusion: Repeated hypoxic episodes in OSAS resulted in statistically significant impairments in the central auditory pathways, even if the hearing threshold was within normal limits.

摘要

背景/目的:阻塞性睡眠呼吸暂停综合征(OSAS)是一种以睡眠期间反复缺氧发作为特征的疾病。缺氧对中枢神经系统的影响是众所周知的。在这项研究中,我们旨在研究 OSAS 对中枢听觉系统的影响。

材料和方法

21 例经多导睡眠图(PSG)诊断为 OSAS 的患者和 10 例对照者纳入本研究。在彻底的耳鼻喉科检查后,所有受试者均进行纯音听力测试(250 至 8000 Hz 频率)。将具有正常耳镜检查和听力阈值的受试者纳入研究。所有参与者均进行言语辨别分析以及听觉时间处理和排序测试,即频率模式测试(FPT)和持续时间模式测试(DPT)。

结果

尽管 OSAS 患者的听力正常,但与对照组相比,其言语辨别率明显下降(P < 0.05)。在 OSAS 患者中,FPT 和 SPT 也出现了明显的中断(P < 0.05)。

结论

即使听力阈值在正常范围内,OSAS 中的反复缺氧发作也会导致中枢听觉通路出现统计学上显著的损伤。

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