Seo Young Joon, Chung Hyo Jin, Park Sang Yoo, Kim Chang-Hoon, Lee Jeung-Gweon, Kim Sung Huhn, Cho Hyung-Ju
Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Seoul, South Korea.
Department of Otolaryngology, Yonsei University College of Medicine Seoul, South Korea.
J Clin Sleep Med. 2016 May 15;12(5):653-8. doi: 10.5664/jcsm.5786.
The aims of this study were to determine if a correlation exists between the level of hypoxia induced by severe obstructive sleep apnea syndrome (OSAS) and the level of auditory dysfunction when verifying such a relationship using polysomnography (PSG).
A retrospective review of 41 patients with severe OSAS was performed. Independent risk factors for hearing impairment included parameters of PSG, which were analyzed in two hearing groups at a level ≥ 40 decibels (dB).
Oxyhemoglobin saturation, especially the lowest oxyhemoglobin saturation level, showed lower thresholds in the hearing impairment group than in the control group (p = 0.039 at NREM stage; p = 0.029 at REM stage; p = 0.001 at total sleep stage). After adjusting for other risk factors, the sole variable that remained significant was lowest oxyhemoglobin saturation (total; p = 0.046). In the correlation analysis, a decreasing lowest oxyhemoglobin saturation (from all subjects, n = 41) correlated with a greater mean hearing threshold (R(2) = 0.297; p < 0.001).
Our results indicated that lowest oxyhemoglobin saturation in PSG is the only variable correlated with the hearing threshold. This finding could be predictive of possible hearing alternation in patients with severe OSAS.
A commentary on this article appears in this issue on page 641.
本研究旨在通过多导睡眠监测（PSG）来验证严重阻塞性睡眠呼吸暂停综合征（OSAS）所致低氧水平与听觉功能障碍水平之间是否存在相关性。
对41例重度OSAS患者进行回顾性研究。听力损害的独立危险因素包括PSG参数，在两个听力组中对≥40分贝（dB）水平的参数进行分析。
氧合血红蛋白饱和度，尤其是最低氧合血红蛋白饱和度水平，在听力损害组中的阈值低于对照组（非快速眼动期p = 0.039；快速眼动期p = 0.029；全睡眠期p = 0.001）。在调整其他危险因素后，唯一仍具有显著意义的变量是最低氧合血红蛋白饱和度（全睡眠期；p = 0.046）。在相关性分析中，最低氧合血红蛋白饱和度降低（所有受试者，n = 41）与更高的平均听力阈值相关（R(2)=0.297；p < 0.001）。
我们的结果表明，PSG中的最低氧合血红蛋白饱和度是与听力阈值相关的唯一变量。这一发现可预测重度OSAS患者可能出现的听力改变。
关于本文的一篇述评发表在本期第641页。
