HBV 患者肝纤维化进展过程中 PK2 与枯否细胞数量的关系。

Relationship between PK2 and number of Kupffer cells during the progression of liver fibrosis in patients with HBV.

出版信息

Turk J Med Sci. 2018 Feb 23;48(1):52-61. doi: 10.3906/sag-1705-32.

Abstract

Background/aim: This study aimed to investigate the potential regulatory role of prokineticin 2 (PK2) in modulation of the number and function of Kupffer cells (KCs) during the progression of liver fibrosis in patients with hepatitis B virus (HBV). Materials and methods: We obtained liver tissue sections from 200 patients with HBV undergoing surgical resection in our hospital between January 2013 and July 2016. Of these 200 tissue sections, 150 were fibrosis tissues and 50 were hepatocellular carcinoma tissues. Immunohistochemical evaluations were performed to assess the expression levels of CD68 and PK2 in the sections. The clinical parameters of these 200 patients were also analyzed. Results: As a potential cytokine, PK2 was commonly expressed in KCs. In addition, a close correlation between PK2 and the number of KCs during the progression of liver fibrosis in patients with HBV was found in this study. Conclusion: PK2 is expressed in KCs and participates in the progression of liver fibrosis after HBV infection. As a potential cytokine, PK2 modulates the number of KCs during fibrosis. Thus, PK2 most likely adjusts the number of M1 cells to modulate the role of KCs in the progression of liver fibrosis after HBV infection.

摘要

背景/目的：本研究旨在探讨促胃动素 2（PK2）在乙型肝炎病毒（HBV）感染患者肝纤维化进展过程中调节枯否细胞（KC）数量和功能中的潜在调节作用。材料和方法：我们从 2013 年 1 月至 2016 年 7 月在我院接受手术切除的 200 例 HBV 患者的肝组织切片中获得。在这 200 个组织切片中，有 150 个是纤维化组织，50 个是肝细胞癌组织。进行免疫组织化学评估以评估切片中 CD68 和 PK2 的表达水平。还分析了这 200 例患者的临床参数。结果：作为一种潜在的细胞因子，PK2 在 KC 中普遍表达。此外，本研究发现 PK2 与 HBV 感染患者肝纤维化进展过程中 KC 数量之间存在密切相关性。结论：PK2 在 KC 中表达，并参与 HBV 感染后肝纤维化的进展。作为一种潜在的细胞因子，PK2 在纤维化过程中调节 KC 的数量。因此，PK2 可能通过调节 M1 细胞的数量来调节 KC 在 HBV 感染后肝纤维化进展中的作用。