a Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development , East China Normal University , Shanghai , People's Republic of China.
d State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , People's Republic of China.
Nat Prod Res. 2019 Aug;33(16):2314-2321. doi: 10.1080/14786419.2018.1443100. Epub 2018 Feb 25.
Three new acetophenones, named cynwilforones A-C (-), together with cynandione A () were isolated from the root bark of (Maxim.) Hemsl. Their structures were deduced based on spectroscopic analysis and chemical methods. Compounds and exhibited potential hypoglycemic effects through inhibition of hepatic gluconeogenesis by down-regulating the expression of phosphoenolpyruvate carboxykinase and glucose-6-phosphatase. This is the first report that acetophenones from the root bark of possesses potential hypoglycemic activity .
从（Maxim.）Hemsl 的根皮中分离得到了三种新的苯乙酮，分别命名为 cynwilforones A-C（-），以及 cynandione A（）。它们的结构是基于光谱分析和化学方法推断出来的。化合物和通过下调磷酸烯醇丙酮酸羧激酶和葡萄糖-6-磷酸酶的表达来抑制肝糖异生，显示出潜在的降血糖作用。这是首次报道从根皮中分离得到的苯乙酮具有潜在的降血糖活性。
