Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Chemistry and Chemical Engineering , Shanghai Jiao Tong University , 800 Dongchuan Road , Shanghai 200240 , P. R. China.
Department of Chemistry, Graduate School of Science , Tohoku University , Aramaki 3-6, Aoba-ku , Sendai 980-8578 , Japan.
Org Lett. 2018 Mar 16;20(6):1608-1612. doi: 10.1021/acs.orglett.8b00352. Epub 2018 Feb 26.
Pd(II)-catalyzed intermolecular 1,2-aminooxygenation and 1,2-oxyamination of conjugated dienes have been developed. The chemoselective preparation of a variety of 2-functionalized and 3-functionalized 1,4-benzoxazine derivatives was accomplished via the adjustment of a coordinating solvent. Oxygen was successfully used in this oxidative difunctionalization of alkenes. Good yields and selectivities were obtained for most products. A product bearing a spiro structure was also obtained from a 2,3-disubstituted-1,3-diene.
Pd(II)催化的共轭二烯的分子间 1,2-氨基氧化和 1,2-氧胺化已经被开发出来。通过调节配位溶剂，可以实现各种 2-官能化和 3-官能化 1,4-苯并恶嗪衍生物的选择性制备。氧气在烯烃的这种氧化双官能化中被成功地使用。大多数产物都获得了良好的产率和选择性。一个带有螺结构的产物也可以从 2,3-二取代的 1,3-二烯中得到。
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