Simek J, Shcherbakov V I, Mayansky D N, Vosvrdová H, Cervinková Z, Holecek M
Physiol Bohemoslov. 1986;35(5):473-80.
Stimulation of the Kupffer cells with E. coli endotoxin (the purified lipopolysaccharide) or with prodigiosan (a polysaccharide from Serratia marcescens) 24 h before partial hepatectomy (resection of 65-70% of the liver) stimulated and intensified the onset of liver regenerative activity (evaluated from changes in liver DNA synthesis, the H5 labelling index and the mitotic activity of the hepatocytes). Liver DNA synthesis increased together with the dose of endotoxin (i.v., from 25 to 1000 micrograms/kg body weight). If E. coli endotoxin was injected during or 3 h after partial hepatectomy, partial inhibition of liver DNA synthesis was observed. In mice stimulated with zymosan (a polysaccharide isolated from yeast), administered 5 days before performing partial hepatectomy, proliferation of the hepatocytes (evaluated from changes in the 3H labelling index and in the mitotic activity of the hepatocytes) was evaluated. The results confirm that proliferation is correlated to the state of reactivity of the Kupffer cells.
在部分肝切除术（切除65 - 70%的肝脏）前24小时，用大肠杆菌内毒素（纯化的脂多糖）或灵菌红素（粘质沙雷氏菌的一种多糖）刺激库普弗细胞，可刺激并增强肝脏再生活动的开始（根据肝脏DNA合成、H5标记指数和肝细胞有丝分裂活性的变化来评估）。肝脏DNA合成随内毒素剂量（静脉注射，从25至1000微克/千克体重）增加。如果在部分肝切除术中或术后3小时注射大肠杆菌内毒素，则会观察到肝脏DNA合成受到部分抑制。在用酵母聚糖（从酵母中分离出的一种多糖）刺激的小鼠中，于进行部分肝切除术5天前给药，评估肝细胞的增殖情况（根据3H标记指数和肝细胞有丝分裂活性的变化来评估）。结果证实，增殖与库普弗细胞的反应状态相关。
