Grape seed proanthocyanidins and metformin combination attenuate hepatic endoplasmic reticulum stress in rats subjected to nutrition excess.

CONTEXT

Endoplasmic reticulum (ER) stress in the liver is a pathological outcome of nutrient excess and is suggested to be one of the hits for progressive liver injury.

OBJECTIVE

This study investigated whether grape seed proanthocyanidins (GSP) and metformin (MET) alone or in combination can relieve hepatic ER stress induced in rats subjected to calorie excess.

MATERIAL AND METHODS

Male albino Wistar rats were given high calorie diet (HCD) for 45 days, while GSP (100 mg/kg body weight) and MET (50 mg/kg body weight) were administered either alone or in combination for last 15 days.

RESULTS

GSP, MET or both had reduced the levels of ER stress markers and chaperons, and suppressed the activation of lipogenic and inflammatory mediators in rat liver.

DISCUSSION

Though GSP and MET had reduced ER stress and inflammation individually, combination treatment with GSP + MET was more effective.

CONCLUSION

We suggest intervention with GSP and MET intake has to be considered for the management of liver disorders.