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葡萄籽原花青素改善镉诱导的大鼠睾丸毒性的分子和生化见解：PI3K/Akt/Nrf-2 信号通路的作用。

The molecular and biochemical insight view of grape seed proanthocyanidins in ameliorating cadmium-induced testes-toxicity in rat model: implication of PI3K/Akt/Nrf-2 signaling.

机构信息

Department of Zoology, Annamalai University, Chidambaram 608002, India.

Department of Biochemistry, St. Joseph's College, Cuddalore 607001, India.

出版信息

Biosci Rep. 2019 Jan 15;39(1). doi: 10.1042/BSR20180515. Print 2019 Jan 31.

DOI:10.1042/BSR20180515
PMID:30355647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6331675/
Abstract

The present study aims to evaluate the protective effect of grape seed proanthocyanidins (GSP) on cadmium (Cd)-induced testicular apoptosis, inflammation, and oxidative stress in rats. A total of 24 male Wistar rats were divided into four groups, namely control, GSP (100 mg/kg BW), Cd (5 mg/kg BW), and Cd+GSP. Cd-treated rat testes exhibited a significant increment in oxidative stress mediated inflammation and apoptosis. Pre-administration of GSP exhibit significant protection against the apoptotic and inflammatory damages elicited by Cd and uphold the intercellular antioxidant status in testes. Histological changes were studied and the immunohistochemical staining for caspase 3, HSP70, and eNOS protein expressions were also analyzed to justify the protective action of GSP. Furthermore, GSP prevented DNA damage, and enhanced the expression of antioxidant responsive elements Nrf2/HO-1 by PI3K/Akt-dependent pathway. Therefore, our results suggest that GSP acts as a multipotent antioxidant entity against Cd-induced oxidative testicular toxicity in rats.

摘要

本研究旨在评估葡萄籽原花青素（GSP）对镉（Cd）诱导的大鼠睾丸细胞凋亡、炎症和氧化应激的保护作用。将 24 只雄性 Wistar 大鼠分为四组，分别为对照组、GSP（100mg/kgBW）组、Cd（5mg/kgBW）组和 Cd+GSP 组。Cd 处理的大鼠睾丸表现出氧化应激介导的炎症和细胞凋亡的显著增加。GSP 的预先给药对 Cd 引起的细胞凋亡和炎症损伤表现出显著的保护作用，并维持睾丸内的细胞间抗氧化状态。研究了组织学变化，并分析了 caspase 3、HSP70 和 eNOS 蛋白表达的免疫组织化学染色，以证明 GSP 的保护作用。此外，GSP 可防止 DNA 损伤，并通过 PI3K/Akt 依赖性途径增强抗氧化反应元件 Nrf2/HO-1 的表达。因此，我们的结果表明，GSP 作为一种多效抗氧化剂，可对抗大鼠镉诱导的氧化睾丸毒性。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/070a/6331675/5e39c090f748/bsr-39-bsr20180515-g8.jpg
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