Hutter J J, Hays T, Rosen R C, Shende A, Lanzkowsky P, Corrigan J J
Am J Hematol. 1979;6(4):333-41. doi: 10.1002/ajh.2830060405.
Two children who presented initially with a lymphoid malignancy were noted to develop recurrences with myeloid features late in the course of their disease. In both cases, evidence of lymphoid differentiation was present in the myelogenous cells that were Ph1 chromosome negative. The first patient had acute myelogenous leukemia and developed a recurrence with morphologic features of acute myelogenous leukemia. Terminal transferase was present in the myelogenous blasts. The second patient initially had a diffuse lymphoblastic non-Hodgkin lymphoma. During the course of her illness she developed a myeloproliferative disorder characterized by basophilic meningitis, splenomegaly, and hypereosinophilia. Lymphocyte T-cell (E-rosette) markers were present on the eosinophils. These observations lend further support to the hypothesis of varying lymphoid and myeloid differentiation in certain cases of leukemia.
两名最初表现为淋巴系统恶性肿瘤的儿童在病程后期出现了具有髓系特征的复发。在这两个病例中，Ph1染色体阴性的髓系细胞中存在淋巴样分化的证据。第一名患者患有急性髓系白血病，并出现了具有急性髓系白血病形态学特征的复发。末端转移酶存在于髓系母细胞中。第二名患者最初患有弥漫性淋巴细胞性非霍奇金淋巴瘤。在她患病期间，她发展为一种骨髓增殖性疾病，其特征为嗜碱性脑膜炎、脾肿大和嗜酸性粒细胞增多。嗜酸性粒细胞上存在淋巴细胞T细胞（E花环）标志物。这些观察结果进一步支持了某些白血病病例中存在不同淋巴样和髓系分化的假说。
