Ghafoor Rabia, Anwar Muhammad Irfan
Department of Dermatology, Jinnah Postgraduate Medical Centre (JPMC), Karachi.
Department of Dermatology, Bahria University Medical And Dental College (BUMDC) and PNS Shifa, Karachi.
J Coll Physicians Surg Pak. 2018 Mar;28(3):S37-S38. doi: 10.29271/jcpsp.2018.03.S37.
Syphilis is a venereal disease caused by treponema pallidum, historically known as "great mimicker" because of its variable presentations. Secondary syphilis usually presents with maculopapular or papulosquamous rash. Rare manifestations include papulonodular, annular and lichenoid lesions. Nodules are usually found in benign tertiary syphilis. We present a case of a young boy who presented with five months' history of nodular skin lesions and hoarseness of voice. Venereal disease research laboratory (VDRL) was initially negative owing to prozone phenomenon. However, histopathology was confirmatory and he responded to benzathine penicillin. We present this case because of rare clinical presentation with persistent nodular lesions, unusual age group, and negative initial VDRL test.
梅毒是由梅毒螺旋体引起的一种性传播疾病,因其临床表现多样,在历史上被称为“伟大的模仿者”。二期梅毒通常表现为斑丘疹或丘疹鳞屑性皮疹。罕见表现包括丘疹结节性、环状和苔藓样病变。结节通常见于良性三期梅毒。我们报告一例年轻男孩,有5个月的结节性皮肤病变和声音嘶哑病史。由于前带现象,性病研究实验室(VDRL)初筛最初为阴性。然而,组织病理学检查确诊,且他对苄星青霉素治疗有反应。我们报告此病例是因为其临床表现罕见,有持续性结节性病变、不寻常的年龄组以及初筛VDRL试验阴性。