Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada; Discipline of Oncology, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Discipline of Genetics, Faculty of Medicine, Memorial University, St. John's, NL, Canada.
Crit Rev Oncol Hematol. 2018 Mar;123:114-131. doi: 10.1016/j.critrevonc.2018.01.009. Epub 2018 Feb 6.
SWI/SNF is a multiprotein complex essential for regulation of eukaryotic gene expression. In this article, we review the function and characteristics of this complex and its subunits in cancer-related phenotypes. We also present and discuss the publically available survival analysis data for TCGA patient cohorts, revealing novel relationships between the expression levels of the SWI/SNF subunit genes and patient survival times in several cancers. Overall, multiple lines of research point to a wide-spread role for the SWI/SNF complex genes in human cancer susceptibility and patient survival times. Examples include the mutations in ARID1A with cancer-driving effects, associations of tumor SWI/SNF gene expression levels and patient survival times, and two BRM promoter region polymorphisms linked to risk or patient outcomes in multiple human cancers. These findings should motivate comprehensive studies in order to fully dissect these relationships and verify the potential clinical utility of the SWI/SNF genes in controlling cancer.
SWI/SNF 是一个多蛋白复合物，对于真核基因表达的调控至关重要。在本文中，我们综述了该复合物及其亚基在与癌症相关表型中的功能和特征。我们还呈现和讨论了 TCGA 患者队列的公共生存分析数据，揭示了 SWI/SNF 亚基基因表达水平与几种癌症患者生存时间之间的新关系。总的来说，多条研究线索指向 SWI/SNF 复合物基因在人类癌症易感性和患者生存时间中的广泛作用。例如，ARID1A 的突变具有致癌作用，肿瘤 SWI/SNF 基因表达水平与患者生存时间之间的关联，以及两个 BRM 启动子区域多态性与多种人类癌症的风险或患者结局相关。这些发现应该促使进行全面的研究，以充分剖析这些关系，并验证 SWI/SNF 基因在控制癌症方面的潜在临床应用。
