Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Neurodegeneration Imaging Group, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Sleep Med. 2018 Mar;43:25-30. doi: 10.1016/j.sleep.2017.11.1137. Epub 2017 Dec 12.
OBJECTIVES/BACKGROUND: Excessive daytime sleepiness (EDS) is a common disorder, which can manifest in isolation or in combination with other neurological or psychiatric disorders. We know relatively little about the mechanisms underlying the development of EDS and the clinical management of patients with EDS remains an unmet need. In this study, we hypothesised that thalamic dopaminergic function would be altered in subjects with EDS and we sought to investigate this by assessing [I]FP-CIT Single Photon Emission Computed Tomography (SPECT) data, which is a molecular imaging marker of dopamine transporter (DAT).
PATIENTS/METHODS: We performed a case-control study using people registered as healthy subjects in the Parkinson's Progression Markers Initiative database. We assessed and compared semi-quantified [I]FP-CIT-SPECT in two groups of 21 healthy subjects with and without EDS, who were matched for age, gender, years of education and Rapid eyemovement (REM) sleep behaviour disorder (RBD) Questionnaire scores.
Our findings show increased thalamic DAT binding in people with EDS compared to matched healthy subjects without EDS. Higher thalamic DAT binding also correlated with worse EDS scores.
Our findings provide evidence that increased dopaminergic function in the thalamus may mediate excessive daytime sleepiness in humans.
目的/背景：日间嗜睡（EDS）是一种常见的疾病，它可以单独出现，也可以与其他神经或精神疾病同时出现。我们对 EDS 发展的机制知之甚少，而 EDS 患者的临床管理仍然是一个未满足的需求。在这项研究中，我们假设丘脑多巴胺能功能在 EDS 患者中会发生改变，并通过评估[I]FP-CIT 单光子发射计算机断层扫描（SPECT）数据来研究这一点，这是一种多巴胺转运体（DAT）的分子成像标志物。
患者/方法：我们使用帕金森病进展标志物倡议数据库中登记为健康受试者的人进行了病例对照研究。我们评估并比较了两组 21 名 EDS 患者和 21 名无 EDS 的匹配健康受试者的半定量[I]FP-CIT-SPECT，这些受试者在年龄、性别、受教育年限和快速眼动（REM）睡眠行为障碍（RBD）问卷评分方面相匹配。
我们的研究结果表明，与无 EDS 的匹配健康受试者相比，EDS 患者的丘脑 DAT 结合增加。较高的丘脑 DAT 结合也与 EDS 评分恶化相关。
我们的研究结果提供了证据，表明丘脑多巴胺能功能的增加可能介导了人类的日间嗜睡。
