Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado.
Int J Radiat Oncol Biol Phys. 2021 May 1;110(1):196-205. doi: 10.1016/j.ijrobp.2017.12.290. Epub 2018 Jan 6.
Stereotactic body radiation therapy (SBRT) has emerged as an effective, noninvasive treatment option for primary liver cancer and metastatic disease occurring in the liver. Although SBRT can be highly effective for establishing local control in hepatic malignancies, a tradeoff exists between tumor control and normal tissue complications. The objective of the present study was to review the normal tissue dose-volume effects for SBRT-induced liver and gastrointestinal toxicities and derive normal tissue complication probability models.
立体定向体部放射治疗（SBRT）已成为原发性肝癌和肝脏转移性疾病的一种有效、非侵入性的治疗选择。虽然 SBRT 对于肝脏恶性肿瘤的局部控制非常有效，但在肿瘤控制和正常组织并发症之间存在权衡。本研究的目的是回顾 SBRT 诱导的肝和胃肠道毒性的正常组织剂量-体积效应，并得出正常组织并发症概率模型。
