Satolli Francesca, Rovesti Miriam, Zucchi Alfredo, Gandolfi Marco, Feliciani Claudio, Tchernev Georgi, Wollina Uwe, Gianfaldoni Serena, Lotti Torello
Dermatology, Via Gramsci 14, Parma, Parma 43126, Italy.
"Onkoderma"- Policlinic for Dermatology and Dermatologic Surgery, Sofia, Bulgaria.
Open Access Maced J Med Sci. 2018 Jan 7;6(1):76-78. doi: 10.3889/oamjms.2018.039. eCollection 2018 Jan 25.
Histiocytic sarcoma (HS) is an extremely rare, non-Langerhans cell tumor. HS affects especially adults, its etiology is unknown yet. Skin could be interested by papules or nodules, single or multiple.
A Caucasian man in his late 40s came to our clinic for a naevi evaluation. During the visit, a rose papulonodular lesion was observed in the lumbar region. This lesion was completely asymptomatic, and it had been there for an indefinite period. The clinical evaluation revealed that the lesion appeared elevated, of 9 x 15 mm in dimension, symmetrical and of a homogeneous pinkish colour. The videodermoscopical evaluation revealed a homogeneous yellow central pattern, polymorphic vessels, an eccentric peripheral pigmentation and a white collar. An excisional biopsy was performed. The morphology and the expression of CD163, CD68 and/or lysozyme to the immunophenotypic analysis, revealed the true nature of the lesion.
HS is usually diagnosed at an already advanced clinical stage and it has a high mortality rate even today. Dermoscopy, showing a yellow and distributed homogeneously colour, can facilitate its hard diagnosis.
组织细胞肉瘤(HS)是一种极其罕见的非朗格汉斯细胞肿瘤。HS尤其好发于成年人,其病因尚不清楚。皮肤可能出现丘疹或结节,可为单个或多个。
一名40多岁的白种男性因痣的评估前来我们诊所就诊。就诊期间,在腰部发现一个玫瑰色丘疹结节性病变。该病变完全无症状,已存在一段时间。临床评估显示,病变隆起,大小为9×15毫米,对称,呈均匀的粉红色。视频皮肤镜评估显示中央为均匀的黄色模式、多形性血管、偏心性周边色素沉着和白色晕圈。进行了切除活检。对CD163、CD68和/或溶菌酶的形态学及免疫表型分析揭示了病变的真实性质。
HS通常在临床晚期才被诊断出来,即使在今天其死亡率也很高。皮肤镜检查显示均匀分布的黄色,有助于其诊断困难问题的解决。