Çulpan Meftun, Yıldırım Asıf, Turan Turgay, Çaşkurlu Turhan
Department of Urology, İstanbul Medeniyet University Göztepe Training and Research Hospital, İstanbul, Turkey.
Turk J Urol. 2018 Jan;44(1):75-78. doi: 10.5152/tud.2017.29660. Epub 2017 Dec 19.
Prostate cancer is the most common non-cutaneous malignancy and the second cause of cancer death in men. Despite improvements in diagnostic methods, the primary diagnosis of a number of patients may still be on metastatic stage. Cutaneous and supraclavicular lymph nodes are very rare metastatic sites for prostate cancer. In this report we present an extremely rare prostate cancer case diagnosed with supraclavicular lymph node and then developed cutaneous metastasis. A 64 year-old man was admitted to an internal medicine outpatient clinic with supraclavicular lymph node and biopsy of lymph node showed an adenocarcinoma. After prostate cancer diagnosis, patient was treated with androgen deprivation therapy, docetaxel chemotherapy and abiraterone acetate, respectively. While abiraterone treatment, cutaneous metastasis developed in inguinal area and diagnosis was confirmed by skin biopsy. In some cases, atypical symptoms may guide us to find disease with aggressive clinics. That's why, physical rectal examination and prostate specific antigen measurements should be kept in mind for prostate cancer in male patients with supraclavicular lymph node or atypical metastasis.
前列腺癌是最常见的非皮肤恶性肿瘤，也是男性癌症死亡的第二大原因。尽管诊断方法有所改进，但许多患者的初次诊断仍可能处于转移阶段。皮肤和锁骨上淋巴结是前列腺癌极为罕见的转移部位。在本报告中，我们呈现了一例极为罕见的前列腺癌病例，该病例最初诊断为锁骨上淋巴结转移，随后出现了皮肤转移。一名64岁男性因锁骨上淋巴结肿大入住内科门诊，淋巴结活检显示为腺癌。前列腺癌确诊后，患者分别接受了雄激素剥夺治疗、多西他赛化疗和醋酸阿比特龙治疗。在接受阿比特龙治疗期间，腹股沟区出现了皮肤转移，皮肤活检确诊。在某些情况下，非典型症状可能会引导我们发现具有侵袭性临床特征的疾病。这就是为什么对于有锁骨上淋巴结或非典型转移的男性患者，应牢记进行直肠指检和前列腺特异性抗原检测以排查前列腺癌。
