Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan, China.
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong.
Cell Prolif. 2018 Aug;51(4):e12441. doi: 10.1111/cpr.12441. Epub 2018 Feb 26.
Tumour necrosis factor alpha (TNFα) and interferon gamma (IFNγ) were originally found to be produced by inflammatory cells and play important roles in the immune system and surveillance of tumour growth. By activating distinct signalling pathways of nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and JAK/STAT, TNFα and IFNγ were reported to effectively trigger cell death and perform powerful anti-cancer effects. In this review, we will discuss the new advancements of TNFα and IFNγ in anti-cancer therapy.
肿瘤坏死因子-α（TNFα）和干扰素-γ（IFNγ）最初被发现由炎症细胞产生，在免疫系统和肿瘤生长监测中发挥重要作用。TNFα 和 IFNγ 通过激活核因子-κB（NF-κB）、丝裂原活化蛋白激酶（MAPK）和 JAK/STAT 的不同信号通路，被报道能有效地触发细胞死亡并发挥强大的抗癌作用。在这篇综述中，我们将讨论 TNFα 和 IFNγ 在癌症治疗中的新进展。
