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6-磷酸果糖-1-激酶亚基的大鼠组织/器官比例是否具有品系特异性?

Are the rat tissue/organ proportions of 6-phosphofructo-1-kinase subunits strain-specific?

作者信息

Dunaway G A, Kasten T

出版信息

Biochem J. 1986 Jul 1;237(1):157-61. doi: 10.1042/bj2370157.

Abstract

Recent studies suggest that the tissue/organ proportions of 6-phosphofructo-1-kinase (PFK) subunits from diverse strains of rat may be drastically different. To test this possibility rigorously, the PFK isoenzyme populations and subunit contents in muscle, liver, brain and heart were examined in the following strains: Wistar, ACI, Long Evans, Norway Brown and Wag/Rij. Regardless of the strain, adult muscle possessed only the M-type subunit; adult liver contained predominantly the L-type subunit as well as M-type and C-type subunits; and the adult brain and heart exhibited all three subunit types.

摘要

最近的研究表明,来自不同品系大鼠的6-磷酸果糖-1-激酶(PFK)亚基的组织/器官比例可能存在显著差异。为了严格检验这种可能性,对以下品系的大鼠肌肉、肝脏、大脑和心脏中的PFK同工酶群体和亚基含量进行了检测:Wistar、ACI、Long Evans、挪威棕鼠和Wag/Rij。无论品系如何,成年肌肉仅含有M型亚基;成年肝脏主要含有L型亚基以及M型和C型亚基;而成年大脑和心脏则呈现出所有三种亚基类型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41d7/1146960/fd0ec0412866/biochemj00276-0157-a.jpg

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