血卟啉衍生物（光卟啉II）对分离线粒体的光敏化作用：阴离子转运受损。
Hematoporphyrin derivative (Photofrin II) photosensitization of isolated mitochondria: impairment of anion translocation.
作者信息
Atlante A, Moreno G, Passarella S, Salet C
出版信息
Biochem Biophys Res Commun. 1986 Dec 15;141(2):584-90. doi: 10.1016/s0006-291x(86)80213-3.
PMID:2948508
Abstract
Isolated mitochondria have been incubated in the presence of 6 micrograms/ml hematoporphyrin derivative (Photofrin II), and irradiated at lambda = 365 nm. After 2 min irradiation (30 W/m2), a congruent to 50% inhibition of citric cycle intermediates transport is observed with a rather similar photosensitivity for the succinate, citrate or oxaloacetate carriers.
摘要
分离出的线粒体在含有6微克/毫升血卟啉衍生物（卟吩姆钠II）的条件下孵育，并在波长为365纳米处进行照射。照射2分钟（30瓦/平方米）后，观察到柠檬酸循环中间产物转运受到约50%的抑制，琥珀酸、柠檬酸或草酰乙酸载体的光敏性相当相似。
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