Shekhonin B V, Tararak E M, Kolokol'chikova E G, Domogatskiĭ S P, Idel'son G L
Biull Eksp Biol Med. 1987 Jan;103(1):101-4.
Enzymatic activity of cells, antigenic cellular markers and extracellular matrix of the hyperplastic intima of the aorta and carotid arteries was investigated in non-specific aorto-arteritis by immunomorphological and histochemical techniques. The cells of subendothelial layer of thickened arterial intima contained smooth muscle cell myosin, gave positive reactions to myosin ATP-ase and revealed high activity of thiamine pyrophosphatase. Fibronectin and type IV and V collagen were located in close proximity to these cells. The data obtained make it possible to consider these cells as modified smooth muscle cells. Type III collagen was the prevalent type of extracellular matrix of the thickened intima. A great number of blood vessels of the capillary and precapillary types have been found to penetrate into the intima from the adventitia. A possible role of pericytes surrounding newly formed capillaries as the precursors of subendothelial cell population in the hyperplastic intima is discussed.
通过免疫形态学和组织化学技术，研究了非特异性主动脉动脉炎中主动脉和颈动脉增生内膜的细胞酶活性、细胞抗原标志物及细胞外基质。增厚动脉内膜内皮下层的细胞含有平滑肌细胞肌球蛋白，对肌球蛋白ATP酶呈阳性反应，并显示硫胺素焦磷酸酶的高活性。纤连蛋白以及IV型和V型胶原位于这些细胞附近。所获得的数据使我们有可能将这些细胞视为修饰的平滑肌细胞。III型胶原是增厚内膜细胞外基质的主要类型。已发现大量毛细血管和毛细血管前型血管从外膜穿透进入内膜。讨论了新形成毛细血管周围的周细胞作为增生内膜内皮下细胞群前体的可能作用。
