CAS Key Laboratory of Receptor Research and the State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.
University of Chinese Academy of Sciences , Beijing 100049 , China.
J Org Chem. 2018 Mar 16;83(6):3245-3251. doi: 10.1021/acs.joc.8b00149. Epub 2018 Mar 2.
To address the challenge of meta nitration of 6-arylpurine substrates, a versatile ruthenium catalyzed meta C-H nitration is developed. The use of a sterically hindered phosphine ligand is crucial for the catalytic efficiency, and a broad class of 6-arylpurines and nucleosides were found suitable for this process providing corresponding exclusively meta nitrated products in good yields.
为了解决 6-芳基嘌呤底物的间位硝化问题，开发了一种多功能钌催化的间位 C-H 硝化反应。使用位阻大的膦配体对于催化效率至关重要，发现广泛的 6-芳基嘌呤和核苷类化合物适用于该过程，以良好的收率提供相应的完全间位硝化产物。
