[ Zucker 大鼠和 Wistar 大鼠白色脂肪组织中分离出的脂肪细胞的脂解活性比较。3,5,3'-三碘-L-甲状腺原氨酸的体外作用]
[Comparison of the lipolytic activity of adipocytes isolated from white adipose tissue in Zucker and Wistar rats. In vitro effects of 3,5,3'-triiodo-L-thyronine].
作者信息
Loireau A, Chomard P, Autissier N, Dumas P
出版信息
C R Seances Soc Biol Fil. 1986;180(4):441-6.
The in vitro effects of 3,5,3'-triiodo-L-thyronine (L-T3) on (-) epinephrine stimulated lipolytic activity were studied in adipocytes isolated from white adipose tissue of Zucker and Wistar male rats. Basic lipolytic activity was small and nearly insensitive to epinephrine in Zucker genetically obese rats. On the other hand, lipolytic activity was stimulated by epinephrine in Zucker lean rats and Wistar rats in the same way. There was no synergistic interaction between epinephrine and L-T3 on lipolytic activity, since the released glycerol levels were nearly the same. These data corroborate the hypothyroid status of Zucker genetically obese rats.
研究了3,5,3'-三碘-L-甲状腺原氨酸（L-T3）对从Zucker和Wistar雄性大鼠白色脂肪组织分离的脂肪细胞中（-）肾上腺素刺激的脂解活性的体外作用。在Zucker遗传性肥胖大鼠中，基础脂解活性较小且对肾上腺素几乎不敏感。另一方面，肾上腺素以相同方式刺激Zucker瘦大鼠和Wistar大鼠的脂解活性。肾上腺素和L-T3对脂解活性没有协同相互作用，因为释放的甘油水平几乎相同。这些数据证实了Zucker遗传性肥胖大鼠的甲状腺功能减退状态。
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