Department of Molecular Cell Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Department of Molecular Cell Biology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.
Trends Biochem Sci. 2018 Apr;43(4):251-268. doi: 10.1016/j.tibs.2018.02.004. Epub 2018 Feb 24.
Cell division is tightly regulated to disentangle copied chromosomes in an orderly manner and prevent loss of genome integrity. During mitosis, transcriptional activity is limited and post-translational modifications (PTMs) are responsible for functional protein regulation. Essential mitotic regulators, including polo-like kinase 1 (PLK1) and cyclin-dependent kinases (CDK), as well as the anaphase-promoting complex/cyclosome (APC/C), are members of the enzymatic machinery responsible for protein modification. Interestingly, communication between PTMs ensures the essential tight and timely control during all consecutive phases of mitosis. Here, we present an overview of current concepts and understanding of crosstalk between PTMs regulating mitotic progression.
细胞分裂受到严格调控，以有序的方式解开复制的染色体，防止基因组完整性的丢失。在有丝分裂过程中，转录活性受到限制，而翻译后修饰（PTMs）负责功能性蛋白质的调节。有丝分裂必需的调节因子，包括 Polo 样激酶 1（PLK1）和细胞周期蛋白依赖性激酶（CDK），以及后期促进复合物/周期蛋白体（APC/C），都是负责蛋白质修饰的酶机制的成员。有趣的是，PTMs 之间的通讯确保了在有丝分裂的所有连续阶段进行必要的紧密和及时的控制。在这里，我们概述了目前对调节有丝分裂进程的 PTMs 之间相互作用的理解。
