Zlatkutė Eglė, Liutkevičienė Rasa, Vilkevičiūtė Alvita, Glebauskienė Brigita, Kriaučiūnienė Loresa, Jakštienė Silvija, Žaliūnienė Dalia
Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Acta Med Litu. 2017;24(4):177-190. doi: 10.6001/actamedica.v24i4.3613.
The pathogenesis of pituitary adenoma (PA) is complex and poorly understood. It is thought that PA has a multifactorial aetiology; genetic factors also have an impact on PA development. Since and genes play an important role in tumour growth, differentiation and progression, we decided to determine if the frequency of the genotypes of and polymorphisms influence the development of PA.
The study enrolled = 100 patients with PA and = 200 healthy controls (reference group). The genotyping tests of and were carried out using the real-time polymerase chain reaction (PCR) method.
The polymorphism in the gene 1G/1G genotype was more frequent in the group of invasive PA than in the control group: 28.6% vs. 16.5%, = 0.044. The 1G/2G genotype was more frequent in females of the control group compared to PA group females: 50.3% vs. 30.8%, = 0.011. The polymorphism in the MMP-1 gene 1G/1G genotype was more frequent in the active PA group than in the control group: 28.4% vs. 16.5%, = 0.044. FGFR4-R388 did not play any predominant role in PA development.
The gene 1G/1G may play a role in invasive and active PA development.
垂体腺瘤（PA）的发病机制复杂，目前了解甚少。人们认为PA具有多因素病因；遗传因素也对PA的发生发展有影响。由于 和 基因在肿瘤生长、分化和进展中起重要作用，我们决定确定 和 基因多态性的基因型频率是否会影响PA的发生发展。
该研究纳入了100例PA患者和200例健康对照（参照组）。采用实时聚合酶链反应（PCR）方法进行 和 的基因分型检测。
侵袭性PA组中 基因1G/1G基因型的多态性比对照组更常见：28.6% 对16.5%，P = 0.044。与PA组女性相比，对照组女性中1G/2G基因型更常见：50.3% 对30.8%，P = 0.011。活性PA组中MMP - 1基因1G/1G基因型的多态性比对照组更常见：28.4% 对16.5%，P = 0.044。FGFR4 - R388在PA发生发展中未起任何主要作用。
基因1G/1G可能在侵袭性和活性PA的发生发展中起作用。
