Itani Malak, Gunes Burcak Yilmaz, Akaike Gensuke, Behnia Fatemeh
Department of Radiology, University of Washington Medical Center, 1959 NE Pacific St, Seattle, WA 98195 USA.
Department of Nuclear Medicine, Istanbul Research and Training Hospital, Istanbul, Turkey.
Radiol Case Rep. 2017 Dec 2;13(1):265-268. doi: 10.1016/j.radcr.2017.10.029. eCollection 2018 Feb.
In 2012, the Food and Drug Administration (FDA) approved the use of F-18 florbetapir to estimate β-amyloid neuritic plaque density when indicated. A normal scan will show increased radiotracer uptake in the white matter. Mild uptake in salivary glands, skin, muscles, and bones is considered normal. Being a new and infrequently performed study, familiarity with normal biodistribution and variants is important. We hereby present 2 cases with F-18 florbetapir uptake in lacrimal glands. Patients had no symptoms or known systemic conditions to explain this uptake. We speculate that lacrimal gland uptake of F-18 florbetapir could represent a normal variant.
2012年，美国食品药品监督管理局（FDA）批准在有指征时使用F-18氟比他哌来评估β-淀粉样蛋白神经炎性斑块密度。正常扫描显示白质中放射性示踪剂摄取增加。唾液腺、皮肤、肌肉和骨骼有轻度摄取被认为是正常的。作为一项新的且不常进行的研究，熟悉正常生物分布及变异情况很重要。我们在此呈现2例泪腺有F-18氟比他哌摄取的病例。患者没有症状或已知的全身性疾病来解释这种摄取情况。我们推测泪腺摄取F-18氟比他哌可能代表一种正常变异。
