Lipari Flavio G, Zárate Abel H, García Juan J, Basquíera Ana L, Caeiro Juan P
Servicio de Infectología, Hospital Privado Universitario de Córdoba, Argentina.
Servicio de Hematología y Oncología, Hospital Privado Universitario de Córdoba, Argentina.
Rev Chilena Infectol. 2017 Dec;34(6):535-538. doi: 10.4067/S0716-10182017000600535.
Bloodstream infection is a common complication, which can be life-threatening for hematopoietic stem cells transplant recipients.
To analyze the characteristics of bloodstream infections in hematopoietic stem cell transplant recipients.
Observational, retrospective study. We reviewed the records of 451 patients (autologous and allogeneic transplants) from January 2009 to October 2015.
99 positive blood cultures in 73 patients with bloodstream infection (16%) were found. Mortality attributable to infectious causes was 17%. From the 99 bloodstream infection, 63% were caused by gram-negative bacilli (Escherichia coli 45%, Klebsiella spp 23%, Pseudomonas spp 11% Acinetobacter spp % and other bacilli 15%), 33% by gram-positive cocci, 3% by fungi and 1% by gram-positive bacilli. The gram-negative bacilli were ciprofloxacin resistant (81%), piperacillin/tazobactam resistant (48%), extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae (40%), cefepime resistant (39%) and there was no resistance noted to amikacin.
There is a higher frequency of gram-negative bacilli infection, with a high percentage of multiresistant microorganisms and high resistance to empirical antibiotic treatment.
血流感染是一种常见并发症，对造血干细胞移植受者可能危及生命。
分析造血干细胞移植受者血流感染的特征。
观察性回顾性研究。我们回顾了2009年1月至2015年10月期间451例患者（自体和异体移植）的记录。
在73例血流感染患者中发现99份血培养阳性（16%）。感染性原因导致的死亡率为17%。在99例血流感染中，63%由革兰氏阴性杆菌引起（大肠杆菌45%、克雷伯菌属23%、假单胞菌属11%、不动杆菌属%和其他杆菌15%），33%由革兰氏阳性球菌引起，3%由真菌引起，1%由革兰氏阳性杆菌引起。革兰氏阴性杆菌对环丙沙星耐药（81%）、对哌拉西林/他唑巴坦耐药（48%）、产超广谱β-内酰胺酶（ESBL）的肠杆菌科细菌（40%）、对头孢吡肟耐药（39%），对阿米卡星未发现耐药。
革兰氏阴性杆菌感染频率较高，多重耐药微生物比例高，对经验性抗生素治疗耐药性高。
