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[溃疡性结肠炎免疫抑制治疗后出现的直肠弥漫性大B细胞淋巴瘤。1例报告]

[Rectal diffuse large B cell lymphoma appearing after immunosuppression for ulcerative colitis. Report of one case].

作者信息

Quera Rodrigo, Flores Lilian, Simian Daniela, Kronberg Udo, Vial María Teresa, de Guevara David Ladrón, García-Rodríguez María José

机构信息

Clínica Las Condes, Santiago, Chile.

Servicio de Anatomía Patológica, Clínica Las Condes, Santiago, Chile.

出版信息

Rev Med Chil. 2017 Oct;145(10):1342-1348. doi: 10.4067/S0034-98872017001001342.

Abstract

Primary colorectal lymphoma is a rare form of presentation of gastrointestinal tract lymphomas. Inflammatory bowel disease and its treatment are risk factors for its development. We report a 47-year-old male patient with Ulcerative Colitis of two years of evolution, treated initially with azathioprine and later on with infliximab. Due to a relapse in symptoms after the second dose of infliximab, a new coloncoscopy was performed showing a rectal ulcerative lesion, corresponding to a large cell Non-Hodgkin's Lymphoma. The patient was successfully treated with RCHOP chemotherapy (Rituximab cyclophosphamide doxorubicin vincristine prednisone). He is currently in disease remission.

摘要

原发性结直肠淋巴瘤是胃肠道淋巴瘤的一种罕见表现形式。炎症性肠病及其治疗是其发生的危险因素。我们报告一名47岁男性患者,患有病程两年的溃疡性结肠炎,最初用硫唑嘌呤治疗,后来用英夫利昔单抗治疗。由于第二次注射英夫利昔单抗后症状复发,进行了一次新的结肠镜检查,发现直肠有溃疡性病变,确诊为大细胞非霍奇金淋巴瘤。该患者接受RCHOP化疗(利妥昔单抗、环磷酰胺、多柔比星、长春新碱、泼尼松)治疗成功。他目前处于疾病缓解期。

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