Tang Rongbiao, Yan Fuhua, Yang Guo Yuan, Chen Ke Min
Department of Radiology. Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, People's Republic of China.
Neuroscience and Neuroengineering Center, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.
J Synchrotron Radiat. 2018 Mar 1;25(Pt 2):560-564. doi: 10.1107/S1600577517017404. Epub 2018 Feb 14.
Portal vein imaging is an important method for investigating portal venous disorders. However, the diagnostic requirements are not usually satisfied when using single imaging techniques. Diagnostic accuracy can be improved by combining different imaging techniques. Contrast agents that can be used for combined imaging modalities are needed. In this study, the feasibility of using microbubbles containing gadolinium (MCG) as contrast agents for both phase contrast imaging (PCI) and magnetic resonance imaging (MRI) are investigated. MCG were made by encapsulating sulfur hexafluoride (SF) gas with gadolinium and lyophilized powder. Absorption contrast imaging (ACI) and PCI of MCG were performed and compared in vitro. MCG were injected into the main portal trunk of living rats. PCI and MRI were performed at 2 min and 10 min after MCG injection, respectively. PCI exploited the differences in the refractive index and visibly showed the MCG, which were not detectable by ACI. PCI could facilitate clear revelation of the MCG-infused portal veins. The diameter of the portal veins could be determined by the largest MCG in the same portal vein. The minimum diameter of clearly detected portal veins was about 300 µm by MRI. These results indicate that MCG could enhance both PCI and MRI for imaging portal veins. The detection sensitivity of PCI and MRI could compensate for each other when using MCG contrast agents for animals.
门静脉成像 是 研究 门静脉疾病 的 一种 重要 方法。然而，使用单一成像技术时，诊断要求通常 无法 得到满足。通过 结合 不同的成像技术，可以提高诊断准确性。因此 需要 能够 用于 联合成像模式的 造影剂。在本研究中，研究了 使用 含钆微泡（MCG）作为 相衬成像（PCI）和 磁共振成像（MRI）造影剂 的 可行性。MCG 通过 用钆 和 冻干粉末 包裹 六氟化硫（SF）气体 制成。在体外 进行 并 比较了 MCG 的 吸收对比成像（ACI）和 PCI。将 MCG 注入 活体大鼠的 门静脉主干。分别 在 MCG 注射后 2 分钟 和 10 分钟 进行 PCI 和 MRI。PCI 利用 折射率的差异，清晰地显示了 MCG，而 ACI 无法检测到 MCG。PCI 有助于 清晰地显示 注入 MCG 的 门静脉。门静脉直径 可以 通过 同一门静脉中 最大的 MCG 来确定。MRI 检测到的 清晰门静脉的 最小直径 约为 300 µm。这些结果 表明，MCG 可以 增强 PCI 和 MRI 对 门静脉的 成像。在 对 动物 使用 MCG 造影剂时，PCI 和 MRI 的 检测灵敏度 可以 相互补偿。
